First Total Synthesis of (±)-Puyanin and (±)-4′-O-Methylbonannione

✍ Scribed by Yuheng Zhang; Jinhui Yang; Hongjun Li; Shizhi Jiang; Yunfeng Li; Wanyi Liu

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 84 KB
• Volume: 29
• Category: Article
• ISSN: 0256-7660
• DOI: 10.1002/cjoc.201190116

✦ Synopsis

Abstract

A facile approach for the first total synthesis of two naturally occurring geranylated flavonoids, (±)‐puyanin (1) and (±)‐4′‐O‐methylbonannione (2) has been obtained with total yields of 27% and 17.8%, respectively. The key steps were regioselective cyclization of geranylated trihydroxychalcone and regioselective geranylation of 2,4,6‐trihydroxyacetophenone.