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First Total Synthesis of Mappain with a Prenylated and Geranylated Stilbene

✍ Scribed by Lakkoju Chakrapani; Eun Mi Jung; Yong Rok Lee

Book ID
102254624
Publisher
John Wiley and Sons
Year
2010
Tongue
German
Weight
170 KB
Volume
93
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

The first total synthesis of naturally occurring mappain has been achieved by a convergent sequence. The key strategy involved in the synthesis of mappain was a (E)‐stilbene formation by Horner–Wadsworth–Emmons reaction of the corresponding prenylated benzaldehyde with a geranylated benzyl phosphonate.

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