First total synthesis of (±)-AM6898D and its three diastereoisomers by Claisen rearrangement and stereoselective epimerization

✍ Scribed by Yoshio Fukuda; Masahiro Sakurai; Yasushi Okamoto

• Book ID: 104210351
• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 111 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)00598-0

✦ Synopsis

An effective method for the synthesis of (±)-AM6898D and its three diastereoisomers has been established via Claisen rearrangement, stereoselective epimerization of the α-ester stereochemistry and introduction of one isoprene unit by umpolung.