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First total syntheses of the 1,2,3,4-tetrahydronaphtho[2,1-f]isoquinolines annoretine and litebamine

✍ Scribed by M.Carme Pampı́n; Juan C Estévez; Ramón J Estévez; Rafael Suau; Luis Castedo

Book ID
104205680
Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
284 KB
Volume
59
Category
Article
ISSN
0040-4020

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✦ Synopsis

We describe here the first total synthesis of the two natural 1,2,3,4-tetrahydronaphtho[2,1-f]isoquinolines, annoretine and litebamine, from [2-(2-styrylphenyl)ethyl]methylcarbamic acid ethyl esters. The key steps were the Bischler-Napieralski cyclization to form the isoquinoline unit and photocyclization of the resulting 2-methyl-5-styryl-3,4-dihydro-2H-isoquinolin-1-ones to 2-methyl-3,4-dihydro-2H-naphtho[2,1-f]isoquinolin-1-ones.

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ChemInform Abstract: First Total Synthesis of the 1,2,3,4-Tetrahydronaphtho[2,1-f]isoquinoline Annoretine.
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ChemInform Abstract: First Total Synthes
ChemInform Abstract: First Total Synthesis of 1,2,3,4-Tetrahydronaphtho[2,1-f]isoquinolines.
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ChemInform Abstract: Total Syntheses of
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v