First Synthesis of a Steroid Containing an Unstable 19-Nor-androsta-1,5-dien-3-one System.

ChemInform Abstract: A Concise Route to

ChemInform Abstract: A Concise Route to 19-Nor-10-azasteroids, a New Class of Steroid 5α-Reductase Inhibitors. Part 3. Synthesis of (+)-19-Nor-10-azatestosterone and (+)-17β-(Acetyloxy)-(5β)-10-azaestr-1-en-3-one.

✍ A. GUARNA; E. G. OCCHIATO; F. MACHETTI; D. SCARPI 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 43 KB 👁 2 views

A Concise Route to 19-Nor-10-azasteroids, a New Class of Steroid 5α-Reductase Inhibitors. Part 3. Synthesis of (+)-19-Nor-10azatestosterone and (+)-17β-(Acetyloxy)-(5β)-10-azaestr-1-en-3-one. -The title compounds are of interest, since 5α-reductase inhibitors (by reducing the level of dihydrotesto