First Study of Syntheses and Reactivity of Grignard Compounds in the Diazine Series. Diazines. Part 27
✍ Scribed by A Leprêtre; A Turck; N Plé; P Knochel; G Quéguiner
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 153 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0040-4020
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✦ Synopsis
A preparation of Grignard derivatives of diazines is described using a halogen magnesium exchange reaction. This convenient method allows the functionalization of these rings at 0ЊC or even room temperature.
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## Abstract For Abstract see ChemInform Abstract in Full Text.
acid chain was carried out in about 90% yield by catalytic hydrogenolysis of the 2-iodoethyl derivative l c which was prepared from hexamethyl dicyanocobyrinate [2] via the primary alcohol l a and the corresponding mesylate l b (cf. Exper. Part). When oxidized with O2 in the presence of ascorbic aci