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First Stereoselective Synthesis of a Pro-Pro E-Alkene Dipeptide Isostere.

✍ Scribed by Nina G. Bandur; Klaus Harms; Ulrich Koert


Publisher
John Wiley and Sons
Year
2005
Weight
23 KB
Volume
36
Category
Article
ISSN
0931-7597

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✍ Dipl.-Chem. Cédric Reuter; Dr. Peter Huy; Dr. Jörg-Martin Neudörfl; Dr. Ronald K 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 849 KB

## Abstract A practical and scalable synthesis of a Fmoc‐protected tricyclic dipeptide mimetic (**6**), that is, a 1,4‐diaza‐tricyclo‐[8.3.0^3, 7^]‐tridec‐8‐ene derivative resembling a rigidified di‐L‐proline in a polyproline type II (PPII) helix conformation, was developed. The strategy is based o