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First Scale-Up Synthesis of WAY-262398, a Novel, Dual-Acting SSRI/5HT1a Antagonist

✍ Scribed by Nikitenko, Antonia; Alimardanov, Asaf; Afragola, Jay; Schmid, Jean; Kristofova, Livia; Evrard, Deborah; Hatzenbuhler, Nicole T.; Marathias, Vasilios; Stack, Gary; Lenicek, Steve; Potoski, John


Book ID
120273655
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
172 KB
Volume
13
Category
Article
ISSN
1083-6160

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Synthesis of novel WAY 100635 derivative
✍ Matthias M. Herth; Vasko Kramer; Frank RΓΆsch πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 French βš– 265 KB

## Abstract 5‐HT~1A~ receptors are involved in a variety of psychiatric disorders and __in vivo__ molecular imaging of the 5‐HT~1A~ status represents an important approach to analyze and treat these disorders. We report herein the synthesis of three new fluoroethylated 5‐HT~1A~ ligands (AH1.MZ, AH2