First-in-Human Study Demonstrating Pharmacological Activation of Heme Oxygenase-1 in Humans
β Scribed by Bharucha, A E; Kulkarni, A; Choi, K M; Camilleri, M; Lempke, M; Brunn, G J; Gibbons, S J; Zinsmeister, A R; Farrugia, G
- Book ID
- 109845813
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 134 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0009-9236
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## Abstrad Heme oxygenase (HO-1 ) is the rate-limiting enzyme in heme catabolism. HO-1, a stress protein, has been suggested to be involved in defense mechanisms against agents that may induce oxidative stress. It has been proposed that renal HO gene expression regulates important hemoprotein(s) s
## Abstract Heme oxygenaseβ1 (HOβ1), also known as heatβshock protein 32 (HSPβ32), is induced in many cells by a large variety of stimuli. Its induction in nervous system cells following toxic and oxidative stress was suggested to play a protective role. Its presence was recently detected by immuno
Heme oxygenase (HO) is the rate-limiting enzyme in the formation of bilirubin, an antioxidant, and carbon monoxide (CO), a cell cycle modulator and a vasodilator. Cyclooxygenase (COX) is a hemeprotein that catalyzes the conversion of arachidonic acid (AA) to various prostanoids, which play an import