We report the results from the first human trials of a new dry electrode sensor for surface biopotential applications. This sensor uses nanotechnology to improve performance and wearability. Standard electrodes for demanding applications such as EEG require skin preparation and/or the use of electrolytic substances to provide and effective electrical interface. The contact surface of the electrode described here is covered with an array of carbon nanotubes designed for penetration of the outer layers of the skin for improved electrical contact without the use of electrolytic gel. In previous papers we detailed the design concept and reported the results of the initial tests of a first prototype-immersion in saline solution and signal detection in animal skin. In this paper we describe the first human trials of the prototype, which indicate performance on par with state-of-the-art research-oriented wet electrodes. No side effects have been observed 6 months after the tests, and the subject did not report any pain or unusual sensations upon application of the electrode.