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First General, Direct, and Regioselective Synthesis of Substituted Methoxybenzoic Acids by Ortho Metalation

✍ Scribed by Nguyen, Thi-Huu; Chau, Nguyet Trang Thanh; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques


Book ID
120192781
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
172 KB
Volume
72
Category
Article
ISSN
0022-3263

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

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Ortho-substituted aryl ketones are prepared from N-[2-(dimethylamino)ethy]-Nmethylbenzamides via ortho lithiation of intermediate a-amino alkoxides, formed in situ by addition of RLi. also described. An ortho lithiation of N-[2-(dimethylamino)ethyl]-N-methylbenzamide is Tertiary a-amino alkoxides, f