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First Example of Diterpenoids from 14,15-Cyclopimarane in the Roots of Linum usitatissimum

✍ Scribed by Jian-Long Sun; An-Jun Deng; Yan Li; Zhi-Hong Li; Hui Chen; Hai-Lin Qin

Publisher: John Wiley and Sons
Year: 2009
Tongue: German
Weight: 229 KB
Volume: 92
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.200900104

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✦ Synopsis

Chemical investigation of the roots of Linum usitatissimum led to the isolation and characterization of a new diterpenoid, named usitatissimin A (1), together with four known compounds. The structure of the new compound was established by spectroscopic methods, including X-ray crystallographic diffraction analysis that confirmed the relative configuration of 1. This is the first example of a diterpenoid with a novel 6/6/6/3-membered ring system of 14,15-cyclopimarane. In addition, usitatissimin A showed pronounced hepatoprotective activity against d-galactosamine-induced toxicity in WB-F 344 rat hepatic epithelial stem-like cells.

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