Germline and somatic mutation analyses i
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Steven M. Lipkin; Victoria Wang; Dan L. Stoler; Garth R. Anderson; Ilan Kirsch;
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Article
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2001
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John Wiley and Sons
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English
β 262 KB
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DNA mismatch repair is of considerable scientific and medical importance because of its essential role in maintaining genomic integrity, and its association with hereditary non-polyposis colon cancer (HNPCC). Germline mutations in five mismatch repair genes (MLH1, MSH2, PMS1, PMS2, and MSH6) have be