First enantioselective synthesis and determination of the absolute configuration of natural (+)-dehydro-β-monocyclonerolidol

✍ Scribed by Elie Palombo; Gérard Audran; Honoré Monti

• Book ID: 104254176
• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 109 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(03)01562-4

✦ Synopsis

The enantioselective synthesis and determination of the absolute configuration of (+)-dehydro-b-monocyclonerolidol, a natural product isolated from the liverwort P. subobtusa, has been achieved starting from (+)-karahana lactone as an enantiopure building block. Furthermore, the methodology applied provided a new approach towards the known (+)-g-cyclohomocitral, a key intermediate in the sequence, and natural (+)-pallescensone.