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First emergence of “delayed-on” and “dose failure” phenomena in a patient with Parkinson's disease following vagotomy

✍ Scribed by Ruth Djaldetti; Anat Achiron; Ilan Ziv; Eldad Melamed

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
159 KB
Volume
9
Category
Article
ISSN
0885-3185

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✦ Synopsis

Complex response fluctuations represent a major complication of chronic levodopa therapy in patients with Parkinson's disease. Of those, the "wearing off' and "on-off'' phenomena are more widely recognized (1). However, two other subtypes of motor fluctuations, i.e., "delayed-on'' (increased latency from levodopa dose intake to start-up of clinical benefit) and "episodic unresponsiveness" (failure of a dose to turn patient on) are quite common and may significantly contribute to prolongation of daily "off' phases and to patients' functional disability (2,3). Although the "wearing off' and "on-off'

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