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First Catalytic Reductive Coupling of 1,3-Diynes to Carbonyl Partners: A New Regio- and Enantioselective C−C Bond Forming Hydrogenation

✍ Scribed by Huddleston, Ryan R.; Jang, Hye-Young; Krische, Michael J.


Book ID
120484686
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
72 KB
Volume
125
Category
Article
ISSN
0002-7863

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✍ Dr. Peng Liu; Prof. Dr. Michael J. Krische; Prof. Dr. Kendall N. Houk 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 800 KB

## Abstract The mechanism of the rhodium‐catalyzed reductive coupling of 1,3‐diynes and vicinal dicarbonyl compounds employing H~2~ as reductant was investigated by density functional theory. Oxidative coupling through 1,4‐addition of the Rh^I^‐bound dicarbonyl to the conjugated diyne via a seven‐m