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First and second generation H1 histamine receptor antagonists produce different sleep-inducing profiles in rats

✍ Scribed by Katsuya Unno; Tomoya Ozaki; Shahid Mohammad; Saki Tsuno; Masami Ikeda-Sagara; Kazuki Honda; Masayuki Ikeda

Book ID
113589837
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
873 KB
Volume
683
Category
Article
ISSN
0014-2999

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We have previously postulated that mast cells (MC) may act as accessory cells in bone resorption. In this study we obtained evidence that histamine, the most abundant mediator released upon MC degranulation, is one of many factors modulating resorption. As the effect of histamine is mediated through