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Finite element analysis of pharmaceutical tablet compaction using a density dependent material plasticity model

✍ Scribed by Tuhin Sinha; Rahul Bharadwaj; Jennifer S. Curtis; Bruno C. Hancock; Carl Wassgren

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
1017 KB
Volume
202
Category
Article
ISSN
0032-5910

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✦ Synopsis

Finite element method (FEM) simulations of pharmaceutical tablet compaction using a Drucker-Prager Cap (DPC) model are presented in which material properties are relative density (solid fraction) dependent. Results from the solid fraction dependent model are compared to those from a constant property model. Predictions from the solid fraction dependent model more closely match experimental measurements of surface hardness, punch force, and material displacement than the constant property model. These results suggest that FEM simulations using the DPC model should account for material property dependence on local solid fraction.

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