Fingolimod treatment for multiple sclerosis Patients What Do We Do with Varicella?

✍ Scribed by Alexander Winkelmann; Micha Loebermann; Emil C. Reisinger; Hans Peter Hartung; Uwe K. Zettl

• Book ID: 101467977
• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 59 KB
• Volume: 70
• Category: Article
• ISSN: 0364-5134
• DOI: 10.1002/ana.22605

✦ Synopsis

identifying individuals with VAVFL, OCT RNFL imaging has a sensitivity and specificity of 92.3% and 63.3%, respectively (when using the classification criteria described).

RNFL thinning in at least 1 of the 90 quadrants was seen in 36.6% of individuals with normal visual fields, suggesting that RNFL thinning may be detected before VAVFL becomes clinically apparent. Because the interpretation of perimetric results is largely subjective, detection of early/mild visual field loss may be difficult compared to detecting small changes in RNFL thickness. 3 In 5 individuals with mild VAVFL, RNFL thickness was normal in all 90 quadrants. It is possible that these individuals could have normal visual fields that were underestimated because of psychomotor slowing or impaired reaction time.

Longitudinal studies are needed to determine the utility of RNFL imaging in the assessment of VGB-exposed individuals, particularly in the early stages of VGB retinotoxicity, when visual fields may be normal.