## Abstract NKG2D operates as an activating receptor on natural killer (NK) cells and costimulates the effector function of αβ CD8^+^ T cells. Ligands of NKG2D, the MHC class I chain‐related (MIC) and UL16 binding protein (ULBP) molecules, are expressed on a variety of human tumors, including melan
Fine tuning of natural killer cell specificity and maintenance of self tolerance in MHC class I-deficient mice
✍ Scribed by Margarita Salcedo; Malena Andersson; Suzanne Lemieux; Luc Van Kaer; Benedict J. Chambers; Hans-Gustaf Ljunggren
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 172 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0014-2980
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## Abstract The natural killer (NK) cells play an important role in viral infections via their spontaneous cytolytic activity against virus‐infected cells as well as via secreting a variety of soluble mediators. The MHC class I‐binding NK receptors of these cells have emerged as the most important
Mice lacking beta2-microglobulin (beta2m- mice) express greatly reduced levels of MHC class I molecules, and cells from beta2m- mice are therefore highly sensitive to NK cells. However, NK cells from beta2m- mice fail to kill beta2m- normal cells, showing that they are self tolerant. In a first atte