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Fine-Tuning of Modular Amino Alcohol Ligands for the Enantioselective Transfer Hydrogenation of Ketones

✍ Scribed by Mireia Pastó; Antoni Riera; Miquel A. Pericàs

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
104 KB
Volume
2002
Category
Article
ISSN
1434-193X

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✦ Synopsis

A family of stereodefined, modular amino alcohols (3-alkoxy-1-amino-1-phenyl-2-propanols), in which the steric bulk of the alkoxy and amino substituents varies smoothly, has been synthesized from enantiomerically pure phenylglycidol, prepared by Sharpless epoxidation. These amino alcohols have been evaluated as ligands in the catalyzed [(amino alcohol)-(arene)Ru II ] transfer hydrogenation of alkyl aryl ketones, [a] Unitat de Recerca en Sı ´ntesi Asime `trica (URSA-PCB),

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✍ Isidro M. Pastor; Patrik Västilä; Hans Adolfsson 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 349 KB 👁 1 views

A library of novel dipeptide-analogue ligands based on the combination of tert-butoxycarbonyl(N-Boc)-protected alpha-amino acids and chiral vicinal amino alcohols were prepared. These highly modular ligands were combined with [[RuCl(2)(p-cymene)](2)] and the resulting metal complexes were screened a