Fine specificity of the immune response to oxazolones III. Antibodies but not contact sensitivity specific for 2-furyloxazolone are controlled by an Igh-V gene in the mouse
✍ Scribed by Olli Mäkelä; Antonio Matoso-Ferreira; Matti Kaartinen
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 648 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0014-2980
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✦ Synopsis
Fine specificity of the immune response to oxazolones 111. Antibodies but not contact sensitivity specific for 2-furyloxazolone are controlled by an Igh-V gene in the mouse* Early IgM and IgG antibodies of CBA and C3H mice (Igh allotype j) against furyloxazolone (furyl Ox) were found to be heteroclitic, they had a 4-6 times higher affinity for styryloxazolone (styryl Ox) than for furyloxazolone. Anti-fury1 Ox antibodies of six other strains (Igh allotypes a, b, c, e, f o r g) had approximately 100 times higher affinity for furyl Ox than for styryl Ox. The heteroclitic fine-specificity was inherited as an Igh allotype-linked trait. Fury1 Ox-specific contact sensitivity was induced by painting, and its specificity was studied with a recently developed method (Ferreira et al., J . Immunol. 1981Immunol. . 127: 2366)). Small strain differences in specificity were detected. They were not inherited as an Igh allotype-linked trait.