Fine-needle sampling of a case of carcinoma of the breast with neuroendocrine differentiation

✍ Scribed by Chantal Veilleux; Didier Trophilme; Monique Le Charpentier; Bernard Dutrillaux; Jerzy Klijanienko; Philippe Vielh

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 618 KB
• Volume: 14
• Category: Article
• ISSN: 8755-1039
• DOI: 10.1002/(sici)1097-0339(199604)14:3<233::aid-dc7>3.0.co;2-i

✦ Synopsis

Fine-needlesampling was performed in a woman with a left breast lump. The cytologic diagnosis was consistent with a poorly-di fferentiated carcinoma. Cytologic features included rnedium-tolarge, round, and spindle-shaped cells with scanty cytoplasm, nuclear molding, and rosette-like structures. Histology revealed an endocrine pattern. Immunohistochemical staining was positive for epithelial and neuroendocrine markers, and electron microscopy showed many small membrane-bound electron-dense granules, confirming the diagnosis of breast carcinoma with neuroendocrine diyerentiation. DNA flow cytometry and cytogenetic analyses revealed a near-tetraploid tumor.