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Fine-needle aspiration of chondroblastic osteosarcoma of the skull: Report of a case in an 11-year-old girl

✍ Scribed by Dale A. Ellison; Jan F. Silverman; Paul S. Strausbach; Vijay V. Joshi

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 509 KB
Volume: 14
Category: Article
ISSN: 8755-1039
DOI: 10.1002/(sici)1097-0339(199602)14:1<51::aid-dc10>3.0.co;2-c

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✦ Synopsis

We describe an unusual case of chondroblastic osteosarcoma of the skull in an 11-yr-old girl in whom a preoperative diagnosis was made by fine-needle aspiration (FNA) biopsy, followed by histologic confirmation of tissue biopsy and the surgically resected specimen. FNA cytology revealed pleomorphic oval cells with prominent nucleoli along with spindle cells, tumor giant cells, and a chondromyxoid background. The cell block of the aspirated material showed osteoid associated with the malignant cells. Immunocytochemical stains revealed 9100 and vimentin positivity; actin, myoglobin, and cytokeratin stains were negative. Electron microscopy revealed neoplastic cells with chondrocytic differentiation. This case demonstrates the value of FNA biopsy combined with immunocytochemical and ultrastructural studies performed on the aspirated material in diagnosing osteosarcoma from an

unusual location such as the base of the skull. Diagn

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