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Fine-needle aspiration cytology and immunohistology of low-grade adenosquamous carcinoma of the breast

✍ Scribed by Gerardo Ferrara; Oscar Nappi; Mark R. Wick

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 201 KB
Volume: 20
Category: Article
ISSN: 8755-1039
DOI: 10.1002/(sici)1097-0339(199901)20:1<13::aid-dc4>3.0.co;2-#

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✦ Synopsis

Low-grade adenosquamous carcinoma of the breast (LASCB) is a relatively recently-described, rare histotype of breast cancer that has a favorable prognosis. Its principal microscopic features are the presence of ''syringoid'' (''tadpole''-shaped) ductal profiles of tumor cells, a bland and modestly cellular stromal background, and the variable presence of keratinizing (''epidermoid'') cell groups. As such, the basic image of LASCB is quite similar to that of microcystic adnexal or adenosquamous carcinoma of the skin or ''syringomatous adenoma'' of the nipple. We report the fine-needle aspiration cytologic (FNA) attributes of this neoplasm, as well as its immunohistochemical characteristics and differential diagnosis.

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