We present the fine-needle aspiration (FNA) findings of 4 cases of anaplastic (Ki-1) large-cell lymphoma (ALCL). A primary diagnosis of ALCL was made on FNA material in 2 cases, of which one was a multifocal osseous Ki-1 lymphoma. In the other 2 patients who had a known history of ALCL, FNA was used
Fine-needle aspiration biopsy of ki-1-positive anaplastic large-cell lymphoma
β Scribed by Dr. Mohammed Akhtar; Muhammad Ashraf Ali; Abdulrazzaq Haider; John Antonius; Bo Hainau; Fouad Al Dayel
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 822 KB
- Volume
- 8
- Category
- Article
- ISSN
- 8755-1039
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β¦ Synopsis
Five cases of Ki-I-positive anaplastic large-cell lymphoma diagnosed by fine-needle aspiration biopsy are reviewed, and cytologic, h,ktologic, and ultrastructural findings in these cases are correlated. In all cases, the diagnosis of anaplastic large-cell lymphoma was suggested on the basis of the morphological appearance in aspiration smears. This diagnosis was confirmed by irnrnunohistochemistry, which revealed strong positivity of most of the cells by Ki-I antibody. Two of the lymphomas were T-cell type, one was B-cell type, and the remaining 2 were composed of null cells. In 2 cases, intracytoplasmic inclusions were seen in some of the tumor cells in aspiration smears. These were ultrastructurally correlated with large lysosomal bodies of variable morphology. Fine-needle aspiration combined with immunohistochemistry may be an efective technique for diagnosing this neoplasm.
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## Background: The cytomorphology of anaplastic large cell lymphoma (alcl) is distinctive yet variable. to the authors' knowledge, to date only small case series have described the cytologic findings noted in patients with alcl. the current series is the largest case series presented to date to ret
Background. There is great diversity in the clinical presentation of CD30 (Ki-1)-positive, anaplastic large cell lymphoma (ALCL). The authors report two patients in whom the clinical and morphologic features mimicked gastrointestinal carcinoma. Methods. Surgical pathology specimens were examined us