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Fine mapping of a human chromosome 6 ferritin heavy chain pseudogene: relevance to haemochromatosis

✍ Scribed by K. M. Summers; K. S. Tam; P. B. Bartley; J. Drysdale; H. Y. Zoghbi; J. W. Halliday; L. W. Powell

Book ID: 104663891
Publisher: Springer
Year: 1991
Tongue: English
Weight: 519 KB
Volume: 88
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00206067

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✦ Synopsis

We have used a somatic cell hybrid regional mapping panel for the short arm of chromosome 6, linkage analysis and a population study to map in detail a previously described ferritin heavy chain pseudogene sequence on chromosome 6. Our results show that this sequence maps to the short arm of chromosome 6 centromeric to the glyoxylase locus. The ferritin pseudogene locus is thus distant from the locus for the iron storage disease haemochromatosis, confirming previous evidence that this sequence is not a candidate for the haemochromatosis gene.

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