Finding treasures in frozen cells: new centriole intermediates

✍ Scribed by Susan K. Dutcher

• Book ID: 101710673
• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 148 KB
• Volume: 29
• Category: Article
• ISSN: 0265-9247
• DOI: 10.1002/bies.20594

✦ Synopsis

Abstract

Centriole duplication has been an area of interest since the late 1800s when Boveri suggested that these structures were central organizers for mitosis and cell division. Two groups1, 2 have delineated a linear pathway for centriole assembly. In C. elegans, Pelletier and coworkers1 have identified intermediates in the pathway using cryo‐electron tomography. Surprising, the first intermediate is a hollow tube of 60 nm that increases in diameter and then elongates before acquiring microtubules. Similar structures have not been observed to date in other centrioles. BioEssays 29:630–634, 2007. © 2007 Wiley Periodicals, Inc.