## Abstract In this age of targeted therapy, the failure of most current drugβdiscovery efforts to yield safe, effective, and inexpensive drugs has generated widespread concern. Successful drug development has been stymied by a general focus on target selection rather than clinical safety and effic
Finding New Tricks For Old Drugs: An Efficient Route For Public-Sector Drug Discovery
β Scribed by O'Connor, Kerry A.; Roth, Bryan L.
- Book ID
- 109949927
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 739 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1474-1776
- DOI
- 10.1038/nrd1900
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
Present study aims to improve efficiency and capacity of in vivo rat pharmacokinetic studies for rapid assessment of systemic exposure (AUC and C(max)) of new chemical entities. Plasma concentration-time profiles in rats from structurally diverse compounds were extracted from the Pfizer database. AU