Terms of use
Copyright
Introduction to the Series
Related Titles from SPIE Press
Preface
Glossary of Symbols and Notation
Introduction and Definitions
Motivation
What Is a Biosensor?
Elements of a Biosensor
Example: Immunochromatographic Assays
Types of Biosensors
Non-optical Biosensors
Optical Biosensors
Background
History of Biosensors
Early Milestones in the Development of Biosensors
Later Milestones in the Development of Biosensors
Surface Functionalization and Immobilization of Bioreceptors
Immobilization of Bioreceptors
From Surface Functionalization to Analyte Capture
Common Bioreceptors
More Bioreceptors
Usual Methods of Immobilization
Performance Parameters
Precision and Accuracy
Repeatability, Reproducibility, and Selectivity
Sensitivity
Measurand, Full-Scale, and Dynamic Ranges
Signal-to-Noise Ratio
Minimum Detectable Signal and Saturation
Time Factors and Stability
Practical Aspects
Resolution, Threshold, Calibration, and Hysteresis
Linearity, Offset, and Overload
Deviations from Ideality (Errors)
The Ideal Biosensor
Fundamental Optical Sensing Mechanisms
Fundamental Optical Processes
Transmission, Absorption, and Scattering
Optical Phase Difference and Optical Path Difference
Polarization
Surface Plasmon Resonance
Luminescence
Photoluminescence
Fluorescence
Phosphorescence
Fluorescence Polarization
Detection Methods, Techniques, and Configurations
Absorbance Biosensors
Infrared Spectroscopy
Infrared Vibrational Modes
Scattering Detection
Resonance Rayleigh Scattering
Transduction Based on Reflectance andTransmittance
Interferometric Biosensors
Colorimetric Bioassays
Biosensing Using Ellipsometry
Photonic Crystals
Fluorescence-Based Biosensing
Fluorescence Polarization Detection
Phosphorescence-Based Biosensing
Chemiluminescence
Bioluminescence
Time-Resolved Fluorescence
Evanescent Wave Biosensing
Attenuated Total Reflection Spectroscopy
Fiber-Optic Biosensors
Near-Field Scanning Optical Microscopy
Surface Plasmon Resonance Biosensors
Real-Time SPR Sensing
Phase-Sensitive Biosensing
Optical Heterodyne Detection
Polarimetry
Photoacoustic Spectroscopy
Raman Spectroscopy
Surface-Enhanced Raman Scattering Detection
Planar Optical Waveguides and IntegratedOptical Sensors
Waveguide Interferometer Architectures
MachβZehnder Interferometer
Young Interferometer
Hartmann Interferometer
Dual Polarization Interferometry
Bimodal Waveguide Interferometers
Resonant Waveguide Grating
Antiresonant Reflecting Optical Waveguides
Hollow Waveguides
Photonic Crystal Cavity Biosensors
Resonant Optical Microcavities
Beyond the Visible and Infrared Ranges
Integrated Microfluidic Biosensors
Lab-on-a-Chip Devices
Bioimaging
Applications
Medicine
Infections Caused by Pathogens
Airborne Diseases
Point-of-Care Testing Techniques
Home Monitoring
Optical Biosensors for Therapeutic Drug Monitoring
Food Safety
Common Foodborne Pathogens
Food Industry
Biosensors for the Detection of Foodborne Pathogens
Defense
Important Biological Warfare Agents
Some Optical Biosensors for Biological Warfare Agents
Homeland Security
Environmental Applications
Wearable and Implantable Biosensors
Challenges in Biosensor Commercialization
Equation Summary
References
Index
Author biography