✦ LIBER ✦

Fibrosis Research || Animal Models for Adult Dermal Wound Healing

✍ Scribed by Varga, John; Brenner, David A.; Phan, Sem H.

Book ID: 118214624
Publisher: Humana Press
Year: 2005
Weight: 304 KB
Category: Article
ISBN: 1592599400
DOI: 10.1385/1-59259-940-0:223

No coin nor oath required. For personal study only.

✦ Synopsis

Wound healing in adult mammals proceeds by a series of overlapping highly coordinated events. Dermal wound repair commences with the arrest of hemorrhage followed by an inflammatory response, re-epithelialization of the wound, and formation of granulation tissue within the wound space, culminating in the production of a scar (1,2). In order to study the processes involved in the repair of wounded tissue, we have developed a rodent model utilizing full thickness incisional and excisional dermal wounds, which allow for macroscopic observations and also provide tissue for the histological and immunocytochemical analysis of acute wounds and scarring.

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