Fibrosis in immune control of mammary-tumor growth

✍ Scribed by Jan Vaage

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: French
• Weight: 630 KB
• Volume: 51
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910510225

✦ Synopsis

Abstract

In malignancies, an interruption of growth (dormancy) is sometimes observed. In the immunogenic mammary carcinoma MC2, dormancy followed by regression after a period of growth was observed in 18% of s.c. implants in normal mice. Dormant implants removed for histologic examination were invariably found to be completely surrounded by a highly fibrous stroma. Fibrosis was enhanced in immunized mice, and reduced in immuno‐deficient mice. Surgical disruption of the fibrous capsule around dormant tumors early (19 ± 3 days) in the immune response led more frequently to resumed growth, while later (32 ± 3 days) disruption of the capsule led more frequently to complete regressions. This showed that fibrous capsules that could destroy tumors could also shield them against well‐developed systemic immune mechanisms.