We have characterized the interaction of homodimeric porcine transforming growth factor-pl (TGF-PI) with affinity-purified human plasma fibronectin. Using a solidphase binding assay, we have demonstrated that TGF-01 binds to fibronectin immobilized on Immunlon ITM microtiter plates. TGF-Pl binding i
Fibronectin-associated transforming growth factor
β Scribed by R. A. Fava; D. B. McClure
- Book ID
- 102883950
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 729 KB
- Volume
- 131
- Category
- Article
- ISSN
- 0021-9541
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Abbreviations: TGF- \(\beta\), Transforming Growth Factor-Beta; TGF- \(\alpha\), Transforming Growth Factor-Alpha; EGF, Epidermal Growth Factor; ECM, Extracellular Matrix; LAP, Latency Associated Protein; CAM, Chorio-Allantoic Membrane; PBN, Peripheral Blood Neutrophil; 5-FU, 5-Fluorouracil; 4-HC, 4
## Abstract Regulated splicing of fibronectin (FN) occurs during the mesenchymal to chondrocyte transition and ultimately results in the relative enrichment of an extra domain B (EDB) exonβcontaining FN isoform with the suggestion that FN isoforms may play a functional role in chondrogenesis. Promo
Transforming growth factor-b (TGF-b) is normally secreted in a latent form, and plasmin-mediated proteolytic cleavage of latency-associated peptide (LAP), a component of latent TGF-b complex that makes the complex inactive, activates latent TGF-b. In the present study, we investigated the possible i