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Fibroblasts require protein kinase C activation to respond to hyaluronan with increased locomotion

✍ Scribed by Christine L. Hall; Lisa A. Collis; Jing Bo A; Laurie Lange; Andrew McNicol; John M. Gerrard; Eva A. Turley


Book ID
117640230
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
232 KB
Volume
20
Category
Article
ISSN
0945-053X

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## Abstract Hyaluronan accumulation in the retroorbital connective tissue is one of the pathological features of Graves' ophthalmopathy. Interleukin‐1Ξ² (IL‐1Ξ²) is known to stimulate hyaluronan synthesis in orbital fibroblasts. In the present study, the intracellular signal transduction pathways inv