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Fibroblast growth factor inhibits interferon γ-STAT1 and interleukin 6-STAT3 signaling in chondrocytes

✍ Scribed by Pavel Krejci; Jirina Prochazkova; Vitezslav Bryja; Petra Jelinkova; Katerina Pejchalova; Alois Kozubik; Leslie Michels Thompson; William R. Wilcox


Book ID
113528264
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
993 KB
Volume
21
Category
Article
ISSN
0898-6568

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A small molecule, LLL12 inhibits constit
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## Abstract We characterized the effects of a newly developed signal transducers and activators of transcription 3 (STAT3) inhibitor, LLL12 in multiple myeloma (MM) cells. LLL12 specifically inhibited STAT3 phosphorylation, nuclear localization, DNA binding activity, down‐regulated STAT3 downstream