## Abstract Vascular endothelial growth factor (VEGF) is a major agent in choroidal and retinal neovascularization, events associated with ageβrelated macular degeneration (AMD) and diabetic retinopathy. Retinal pigment epithelium (RPE), strategically located between retina and choroid, plays a cri
Fibroblast growth factor-2 induces stromelysin-1 (MMP3) expression in endothelial cells by activating mitogen-activated protein kinases
β Scribed by Christopher C. Derivaux; Giuseppe Pintucci; Pay-Jen Yu; Eric Silver; Graziano Seghezzi; Eugene A. Grossi; Bryan M. Steinberg; F.Gregory Baumann; Stephen B. Colvin; Paolo Mignatti; Aubrey C. Galloway
- Book ID
- 114353907
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 139 KB
- Volume
- 191
- Category
- Article
- ISSN
- 1072-7515
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Proliferation of endothelial cells is regulated by angiogenic and antiangiogenic factors whose actions are mediated by complex interactions of multiple signaling pathways. Both vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) stimulate cell proliferation and activa