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Fibrinolytic Poly(dimethyl siloxane) Surfaces

✍ Scribed by Hong Chen; Liang Wang; Yanxia Zhang; Dan Li; W. Glenn McClung; Michael A. Brook; Heather Sheardown; John L. Brash

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
380 KB
Volume
8
Category
Article
ISSN
1616-5187

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

PDMS surfaces have been modified to confer both resistance to non‐specific protein adsorption and clot lyzing properties. The properties and chemical compositions of the surfaces have been investigated using water contact angle measurements, ATR FT‐IR spectroscopy, and XPS. The ability of the PEG component to suppress non‐specific protein adsorption was assessed by measurement of radiolabeled fibrinogen uptake from buffer. The adsorption of plasminogen from human plasma to the various surfaces was studied. In vitro experiments demonstrated that lysine‐immobilized surfaces with free ε‐amino groups were able to dissolve fibrin clots, following exposure to plasma and tissue plasminogen activator.

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