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Fibrinogen Gene Mutations Accounting for Congenital Afibrinogenemia

✍ Scribed by MARGUERITE NEERMAN-ARBEZ


Book ID
111396881
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
675 KB
Volume
936
Category
Article
ISSN
0890-6564

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Mutations in the fibrinogen gene cluster
✍ Marguerite Neerman-Arbez; Philippe de Moerloose πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 284 KB

## Communicated by Arupa Ganguly Fibrinogen is synthesized in hepatocytes in the form of a hexamer composed of two sets of three polypeptides (Aa, Bb, and c). Each polypeptide is encoded by a distinct gene, FGA, FGB, and FGG, all three clustered in a region of 50 kb on 4q31. Congenital afibrinogen