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Fibrin degradation and angiogenesis: Quantitative analysis of the angiogenic response in the chick chorioallantoic membrane

✍ Scribed by Dr W. D. Thompson; R. Campbell; T. Evans

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 993 KB
Volume: 145
Category: Article
ISSN: 0022-3417
DOI: 10.1002/path.1711450103

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✦ Synopsis

Fibrin deposition and removal is a feature common to major pathological processes such as wound healing, chronic inflammation and tumour invasion: processes involving the ingrowth of new blood vessels. Low molecular weight fibrin degradation products (MW less than 50,000) are now shown to induce angiogenesis in the chick chorioallantoic membrane (CAM). This effect has also been shown by new quantitative assays to be associated with stimulation of both DNA and protein synthesis. Autoradiography indicates that all cell types in the CAM are stimulated to divide, and it is proposed that fibrin degradation products are a pathological growth factor.

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The chick chorioallantoic membrane model (CAM) has previously been used to demonstrate cell proliferation, characteristic of both angiogenesis and fibrogenesis, after exposure to fibrin degradation products. This model has now been adapted for quantitative in vivo assay of collagen polypeptide synth