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Fibrin binding characteristics of tissue plasminogen activator mutants

✍ Scribed by Keyt, Bruce; Nguyen, Hung; Cachianes, George; Leung, David


Book ID
123088751
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
182 KB
Volume
3
Category
Article
ISSN
0268-9499

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Molecular assembly of plasminogen and tissue-type plasminogen actwator (t-PA) at the surface of fibrin results in the generation of fibrin-bound plasmin and thereby in the dissolution of a clot. This mechanism is triggered by specific interactions of intra-chain surface lysine residues in fibrin wit