Fiber-optic probes for in vivo depth-resolved neuron-activity mapping
✍ Scribed by Lyubov V. Doronina-Amitonova; Il'ya V. Fedotov; Olga I. Ivashkina; Marina A. Zots; Andrei B. Fedotov; Konstantin V. Anokhin; Aleksei M. Zheltikov
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 786 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1864-063X
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✦ Synopsis
Abstract
Specialty fiber probes are used for in vivo depth‐resolved mapping of neuron activity through the optical detection of fluorescent‐protein reporters expressed inside the living brain of anesthetized transgenic mice. Supercontinuum radiation produced by highly nonlinear photonic‐crystal fibers is employed to demonstrate a simultaneous multicolor interrogation of several biomarkers in a model aqueous solution system, thus suggesting the way toward a multiplex mapping of various types of neuron dynamics inside the living brain. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)