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FIAT, the factor-inhibiting ATF4-mediated transcription, also represses the transcriptional activity of the bZIP factor FRA-1

✍ Scribed by René St-Arnaud; Vice Mandic; Bilal Elchaarani

Book ID: 111399563
Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 216 KB
Volume: 1192
Category: Article
ISSN: 0890-6564
DOI: 10.1111/j.1749-6632.2009.05211.x

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## Abstract Parathyroid hormone (PTH) is an essential regulator of endochondral bone formation and an important anabolic agent for the reversal of bone loss. PTH mediates its functions in part by regulating binding of the bone‐related activating transcription factor 4 (ATF4) to the osteoblast‐speci