FIA Determination of Paracetamol in Pharmaceutical Drugs by Using Gold Electrodes Modified with a 3-Mercaptopropionic Acid Monolayer

✍ Scribed by Valber A. Pedrosa; Denise Lowinsohn; Mauro Bertotti

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 79 KB
• Volume: 18
• Category: Article
• ISSN: 1040-0397
• DOI: 10.1002/elan.200503483

✦ Synopsis

A flow injection analysis (FIA) method for the determination of paracetamol in pharmaceutical drugs using a gold electrode modified with a self-assembled monolayer (SAM) of 3-mercaptopropionic acid is described. At optimized experimental conditions the dynamic concentration range was 0.15 to 15.0 mg L À1 with a detection limit of 0.2 mg mL À1 (S/N ¼ 3). The repeatability of current responses for injections of 10 mmol L À1 paracetamol was evaluated to be 3.2% (n ¼ 30) and the analytical frequency was 180 h À1 . The lifetime of the modified electrode was found to be 15 days. The results obtained by using the proposed amperometric method for paracetamol determination in four different drug samples compared well with those found by spectrophotometry.