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Fhit loss in lung preneoplasia: Relation to DNA damage response checkpoint activation

✍ Scribed by Roberto Cirombella; Giuseppe Montrone; Antonella Stoppacciaro; Simona Giglio; Stefano Volinia; Paolo Graziano; Kay Huebner; Andrea Vecchione


Book ID
116335378
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
395 KB
Volume
291
Category
Article
ISSN
0304-3835

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## Abstract The p53 tumor suppressor protein is a critical mediator of cell cycle arrest and apoptosis in response to genotoxic stress. Abrogation of p53 function is a major feature of tumor development and may result in a compromised DNA‐damage response. In our study, we examined the effect of exp