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FGFR3 Mutations Indicate Better Survival in Invasive Upper Urinary Tract and Bladder Tumours

✍ Scribed by Johanna M.M. van Oers; Ellen C. Zwarthoff; Ishtiaq Rehman; Abdel-Rahmene Azzouzi; Olivier Cussenot; Mark Meuth; Freddie C. Hamdy; James W.F. Catto

Book ID
113610879
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
424 KB
Volume
55
Category
Article
ISSN
0302-2838

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Frequent activating mutations of FGFR3 (fibroblast growth factor receptor 3) are found in human urothelial cell carcinomas, particularly in superficial papillary tumours (in 74%-84% of pTaG1-G2), but not in carcinomas in situ (CIS) and at a low rate in invasive tumours (in 16%-21% of pT1-4). In mice