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FGF21 N- and C-termini play different roles in receptor interaction and activation

✍ Scribed by Junming Yie; Randy Hecht; Jennifer Patel; Jennitte Stevens; Wei Wang; Nessa Hawkins; Shirley Steavenson; Steve Smith; Dwight Winters; Seth Fisher; Ling Cai; Ed Belouski; Ching Chen; Mark L. Michaels; Yue-Sheng Li; Richard Lindberg; Minghan Wang; Murielle Véniant; Jing Xu


Book ID
113621107
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
258 KB
Volume
583
Category
Article
ISSN
0014-5793

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## Abstract Fibroblast growth factor 21 is a member of endocrine FGFs subfamily, along with FGF19 and FGF23. It is emerging as a novel regulator with beneficial effects on a variety of metabolic parameters, including glucose and lipid control. FGF21 activity depends on membrane protein βKlotho that