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Fetal hemoglobin expression in compound heterozygotes for −117 (G→A) Aγ HPFH and β039 nonsense thalassemia

✍ Scribed by Paola Pistidda; Laura Frogheri; Lina Oggiano; Luciana Guiso; Laura Manca; Fausto Dore; Bruno Masala; John G. Gilman; Maurizio Longinotti


Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
415 KB
Volume
49
Category
Article
ISSN
0361-8609

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Fetal hemoglobin expression in the compo
✍ Dedoussis, George V.Z.; Sinopoulou, Klio; Gyparaki, Marilena; Loutradis, Aphrodi 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 265 KB 👁 2 views

We studied a family in which two inherited defects of the non-␣-globin cluster segregate: Greek hereditary persistence of fetal hemoglobin (HPFH) and ␤-thalassemia. The compound heterozygote is a healthy man with 43% HbF, G ␥/ A ␥ ratio (27:73) differing from that of 10 simple heterozygotes for the