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Fetal erythropoiesis and the diagnosis and treatment of hemoglobin disorders in the fetus and child

✍ Scribed by Nancy F. Olivieri

Book ID: 114121040
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 809 KB
Volume: 21
Category: Article
ISSN: 0146-0005
DOI: 10.1016/s0146-0005(97)80021-3

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## Abstract Fetal hemoglobin (HbF), the predominant hemoglobin in the fetus, is a mixture of two molecular species (α~2~^G^γ~2~ and α~2~^A^γ~2~) that differ only at position 136 reflecting the products of two nonallelic γ‐globin genes. At the time of birth, HbF accounts for ∼70% of the total Hb. Th