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Fetal and maternal response to intravenous infusion of a thromboxane synthetase inhibitor

✍ Scribed by Cardin, John P.; Ross, Michael G.; Gore Ervin, M.; Victoria^Schaffer, A.; Douglas, Frank L.; Simke, John P.


Book ID
122745299
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
563 KB
Volume
163
Category
Article
ISSN
1097-6868

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## Abstract **BACKGROUND:** Fetal uptake of an antisense oligonucleotide was evaluated after intravenous (i.v.) dosing of ISIS 2105, a 20‐base phosphorothioate oligonucleotide, in timed‐pregnant Sprague‐Dawley rats. **METHODS:** To maximize the potential for fetal exposure, ISIS 2105 was administer