Maternal and fetal distribution of a pho
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Nicole V. Soucy; Jason P. Riley; Michael V. Templin; Richard Geary; Ann de Peyst
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Article
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2006
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John Wiley and Sons
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English
β 137 KB
## Abstract **BACKGROUND:** Fetal uptake of an antisense oligonucleotide was evaluated after intravenous (i.v.) dosing of ISIS 2105, a 20βbase phosphorothioate oligonucleotide, in timedβpregnant SpragueβDawley rats. **METHODS:** To maximize the potential for fetal exposure, ISIS 2105 was administer