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Fetal and adult human liver differ markedly in the fluidity and lipid composition of their microsomal membranes

✍ Scribed by Jaime Kapitulnik; Evelyn Weil; Ron Rabinowitz; Michael M. Krausz

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 760 KB
Volume: 7
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840070113

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✦ Synopsis

The fluidity and lipid composition of the human hepatic microrromal membrane were studied in l l livers from 16to 21-week-old fetuses and in 5 adult livers, and compared with those of fetal and adult rat liver mimosomes. Membrane fluidity was analyzed by measurement of fluorescence polarization using the fluorophore 1,0-diphenyl-l,3,5-hexatriene. The lipid apparent microviscoeity (4) of human fetal liver microsomes was 2.17 2 0.13 poise, as compared with 1.08 f 0.08 poise in adult liver (p < 0.001). Similar differences in

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✍ Michael Inbar; Hanna Ben-Bassat 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 424 KB

## Abstract Twenty‐five human hematopoietic cell lines established from patients with malignant and non‐malignant diseases have been studied for membrane fluidity. The degree of fluidity in the surface membranes was quantitatively monitored by fluorescence polarization analysis of the fluorescence